Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis

Author:

Xia Tian1,Zhu Yuting2,Li Kaiqiang1,Hao Ke1,Chai Yingqian2,Jiang Hongyi2,Lou Chao2,Yu Jiachen2,Yang Wei3,Wang Jilong2,Deng Junjie2,Wang Zhen1

Affiliation:

1. Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College

2. The First Affiliated Hospital of Wenzhou Medical University

3. Zhejiang University School of Medicine

Abstract

Abstract Background Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers with antioxidant and catalytic-like functions that can eliminate ROS to facilitate the polarization of macrophages phenotype from M1 to M2 and alleviate inflammation. Methotrexate (MTX), a first-line RA medication, was loaded into the NPs, which were further modified with bovine serum albumin (BSA) and integrated into dissolving hyaluronic acid-based microneedles (MNs) for transdermal delivery. Result This innovative approach significantly enhanced drug delivery efficiency, reduced RA inflammation, and successfully modulated macrophage polarization toward an anti-inflammatory phenotype. Conclusion This research not only presents a promising drug delivery strategy for RA but also contributes broadly to the field of immune disease treatment by offering an advanced approach for macrophage phenotypic reprogramming.

Publisher

Research Square Platform LLC

Reference48 articles.

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