Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy

Author:

Liu Lu123,Hu Fanlei4,Wang Hui5,Wu Xiaoli6,Eltahan Ahmed Shaker7,Stanford Stephanie8,Bottini Nunzio8,Xiao Haihua9,Bottini Massimo13ORCID,Guo Weisheng7ORCID,Liang Xing-Jie12ORCID

Affiliation:

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, People’s Republic of China

2. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

3. Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, 00133, Italy

4. Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing 100044, People’s Republic of China

5. CAS Key Laboratory for Nanosystem and Hierarchy Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China

6. School of Life Sciences, Tianjin University, Tianjin 300072, People’s Republic of China

7. Translational Medicine Center, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, People’s Republic of China

8. Altman Clinical & Translational Research Institute, University of California San Diego, La Jolla, California 92037, United States

9. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

University of Rome Tor Vergata

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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