Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Author:

Reiner Agnes T.1,Witwer Kenneth W.23,van Balkom Bas W.M.4,de Beer Joel5,Brodie Chaya67,Corteling Randolph L.8,Gabrielsson Susanne9,Gimona Mario1011,Ibrahim Ahmed G.12,de Kleijn Dominique1314,Lai Charles P.15,Lötvall Jan1617,del Portillo Hernando A.1819,Reischl Ilona G.2021,Riazifar Milad2223,Salomon Carlos2425,Tahara Hidetoshi26,Toh Wei Seong27,Wauben Marca H.M.28,Yang Vicky K.29,Yang Yijun30,Yeo Ronne Wee Yeh31,Yin Hang3233,Giebel Bernd34,Rohde Eva1011,Lim Sai Kiang31

Affiliation:

1. a BioSensor Technologies, AIT Austrian Institute of Technology, Vienna, Austria

2. b Departments of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. c Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

4. d Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands

5. e Anjarium Biosciences AG, Zollikon, Switzerland

6. f Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA

7. g Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

8. h ReNeuron Group, Pencoed, United Kingdom

9. i Department of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden

10. j Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria

11. k Department of Blood Group Serology and Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

12. l Capricor Therapeutics, Los Angeles, California, USA

13. m Dept. of Vascular Surgery & Cardiology, Utrecht University, Utrecht, The Netherlands

14. n NUS Surgery & A-STAR, Singapore

15. o Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China

16. p Krefting Research Centre, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

17. q Codiak BioSciences, Woburn, Massachusetts, USA

18. r ICREA at ISGlobal Barcelona Institute for Global Health, Ctr. Int. Health Res. (CRESIB), Hospital Clínic, University of Barcelona, Barcelona, Spain

19. s Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain

20. t Federal Office for Safety in Health Care, Institute Surveillance, Vienna, Austria

21. u Austrian Agency for Health and Food Safety, Institute Surveillance, Vienna, Austria

22. v Department of Pharmaceutical Sciences, University of California, Irvine, California, USA

23. w Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA

24. x Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia

25. y Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

26. z Department of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

27. aa Faculty of Dentistry, National University of Singapore, Singapore

28. bb Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

29. cc Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA

30. dd State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

31. ee Institute of Medical Biology, A*STAR, Singapore

32. ff Department of Chemistry and Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA

33. gg Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, China

34. hh Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Germany

Abstract

Abstract Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,General Medicine

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