Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Author:

Lener Thomas12,Gimona Mario12,Aigner Ludwig1,Börger Verena3,Buzas Edit4,Camussi Giovanni5,Chaput Nathalie67,Chatterjee Devasis89,Court Felipe A.10,Portillo Hernando A. del1112,O'Driscoll Lorraine1314,Fais Stefano15,Falcon-Perez Juan M.1617,Felderhoff-Mueser Ursula18,Fraile Lorenzo19,Gho Yong Song20,Görgens André3,Gupta Ramesh C.2122,Hendrix An23,Hermann Dirk M.24,Hill Andrew F.25,Hochberg Fred26,Horn Peter A.3,Kleijn Dominique de27,Kordelas Lambros28,Kramer Boris W.29,Krämer-Albers Eva-Maria30,Laner-Plamberger Sandra12,Laitinen Saara31,Leonardi Tommaso3233,Lorenowicz Magdalena J.34,Lim Sai Kiang35,Lötvall Jan36,Maguire Casey A.37,Marcilla Antonio3839,Nazarenko Irina40,Ochiya Takahiro41,Patel Tushar42,Pedersen Shona43,Pocsfalvi Gabriella44,Pluchino Stefano32,Quesenberry Peter89,Reischl Ilona G.45,Rivera Francisco J.46,Sanzenbacher Ralf47,Schallmoser Katharina12,Slaper-Cortenbach Ineke48,Strunk Dirk49,Tonn Torsten50,Vader Pieter5152,Balkom Bas W. M. van53,Wauben Marca54,Andaloussi Samir El5255,Théry Clotilde756,Rohde Eva12,Giebel Bernd3

Affiliation:

1. Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria

2. Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

3. Institute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

4. Department of GeneticsCell- and Immunobiology, Semmelweis University, Budapest, Hungary

5. Molecular Biotechnology CenterDepartment of Medical Sciences, University of Turin, Turin, Italy

6. Laboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US23 Inserm, Villejuif, France

7. Centre of Clinical Investigation in Biotherapy CICBT 1248, Institut Gustave Roussy, Villejuif, France

8. Division of Hematology & Oncology, Rhode Island Hospital, Providence, RI, USA

9. The Alpert Medical School of Brown University Providence, RI, USA

10. Department of Physiology Faculty of Biology, Pontificia-Universidad Católica de Chile, Santiago, Chile

11. ICREA at Barcelona Centre for International Health Research (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain

12. Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain

13. School of Pharmacy and Pharmaceutical SciencesTrinity College Dublin, Dublin 2, Ireland;

14. Trinity Biomedical Sciences Institute Trinity College Dublin, Dublin 2, Ireland

15. Anti-Tumor Drugs SectionDepartment of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy

16. Metabolomics Unit CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain

17. IKERBASQUEBasque Foundation for Science, Bilbao, Spain

18. Department of Paediatrics I Neonatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

19. Departament de Producció Animal, ETSEA, Universitat de Lleida, Lleida, Spain

20. Department of Life SciencesPohang University of Science and Technology, Pohang, Republic of Korea

21. Department of Pharmacology and ToxicologyUniversity of Louisville, Louisville, KY, USA

22. James Graham Brown Cancer CenterUniversity of Louisville, Louisville, KY, USA

23. Laboratory of Experimental Cancer Research Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium

24. Department of NeurologyUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

25. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

26. Massachusetts General Hospital, Boston, MA, USA

27. Department of SurgeryYLL School of Medicine, NUS, Singapore, Singapore

28. Department of Bone Marrow TransplantationUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

29. Experimental Perinatology/NeonatologySchool of Mental Health and Neuroscience, School of Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

30. Molecular Cell Biology and Focus Program Translational NeurosciencesUniversity of Mainz, Mainz, Germany

31. Research and Cell ServicesFinnish Red Cross Blood Service, Helsinki, Finland

32. Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK

33. European Molecular Biology LaboratoryEuropean Bioinformatics Institute (EMBL-EBI), Cambridge, UK

34. Department of Cell BiologyCenter for Molecular Medicine, University Medical Center, Utrecht, The Netherlands

35. Institute of Medical BiologyAgency for Science Technology and Research (A*STAR), Singapore, Singapore

36. Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

37. Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

38. Dpto. Biología Celular y ParasitologiaFacultat de Farmacia, Universitat de Valencia, Valencia, Spain

39. Joint Research Unit on EndocrinologyNutrition and Clinical Dietetics, Universitat de València-Health Research Institute La Fe, Valencia, Spain

40. Institute for Environmental Health Sciences and Hospital Infection Control Medical CenterUniversity of Freiburg, Freiburg im Breisgau, Germany

41. Division of Molecular and Cellular MedicineNational Cancer Center Research Institute, Tokyo, Japan

42. Departments of Transplantation and Cancer BiologyMayo Clinic, Jacksonville, FL, USA

43. Centre for Cardiovascular Research, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg University, Aalborg, Denmark

44. Mass Spectrometry and ProteomicsInstitute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy

45. BASG – Bundesamt für Sicherheit im Gesundheitswesen – Federal Office for Safety in Health Care, AGES – Agentur für Gesundheit und Ernährungssicherheit – Austrian Agency for Health and Food Safety, Institut Überwachung – Institute Surveillance, Wien, Austria

46. Institute of Molecular Regenerative MedicineSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;

47. Ralf Sanzenbacher Paul-Ehrlich-Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Federal Institute for Vaccines and Biomedicines, Langen, Germany

48. Cell Therapy Facility Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands

49. Experimental & Clinical Cell Therapy InstituteSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria

50. Institute for Transfusion Medicine DresdenGerman Red Cross Blood Donation Service North-East, Dresden, Germany

51. Laboratory of Clinical Chemistry and HematologyUniversity Medical Center Utrecht, Utrecht, The Netherlands

52. Department of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, UK

53. Department of Nephrology and HypertensionUniversity Medical Center Utrecht, Utrecht, The Netherlands

54. Department of Biochemistry and Cell BiologyFaculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

55. Department of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

56. INSERM U932 Institut Curie, Paris, France

Publisher

Wiley

Subject

Cell Biology,Histology

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