Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA 4-Reference-Cited by-同舟云学术

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Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA 4

Published:2018-07-06 Issue:8 Volume:8 Page:1202-1208
ISSN:2211-5463
Container-title:FEBS Open Bio
language:en
Short-container-title:FEBS Open Bio

Author:

Yellapu Nanda Kumar¹,Kandlapalli Kalpana²,Kandimalla Ramesh³,Adi Pradeepkiran Jangampalli³

Affiliation:

1. Biomedical Informatics Centre Vector Control Research Centre Indian Council of Medical Research Puducherry India

2. Department of Biochemistry Sri Krishnadevaraya University Anantapuramu Andhrapradesh India

3. Garrison Institute on Aging Texas Tech University of Health Science Centre Lubbock TX USA

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12255

Reference23 articles.

1. Two Birds with One Stone: Novel Glucokinase Activator Stimulates Glucose-Induced Pancreatic Insulin Secretion and Augments Hepatic Glucose Metabolism

2. Glucokinase Mutations, Insulin Secretion, and Diabetes Mellitus

3. Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity

4. Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families

5. Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding – explains hyperglycemia in type 2 diabetic patients

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes;Diabetes;2022-10-28

2. Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach;Molecules;2021-11-28

3. An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes;Current Drug Targets;2020-04-20

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