Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding – explains hyperglycemia in type 2 diabetic patients-Reference-Cited by-同舟云学术

Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding – explains hyperglycemia in type 2 diabetic patients

Published:2014-05-15 Issue:4 Volume:33 Page:820-833
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Yellapu Nandakumar¹²,Mahto Manoj Kumar¹,Valasani Koteswara Rao³,Sarma P.V.G.K.⁴,Matcha Bhaskar¹

Affiliation:

1. Division of Animal Biotechnology, Department of Zoology, Sri Venkateswara University, Tirupati, Andhrapradesh 517502, India

2. Biomedical Informatics Center, Vector Control Research Center, Indian Council of Medical Research, Pondicherry, 605006 India

3. Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, 66047 USA

4. Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, 517507 India

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2014.913989

Reference34 articles.

1. Glucokinase Mutations, Insulin Secretion, and Diabetes Mellitus

2. The Protein Data Bank

3. Glucose-Dependent Insulin Release from Genetically Engineered K Cells

4. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase

5. Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

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