Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

Author:

Mollenhauer Brit12,Dakna Mohammed1,Kruse Niels3,Galasko Douglas4,Foroud Tatiana5,Zetterberg Henrik6789,Schade Sebastian1ORCID,Gera Roland G.10,Wang Wenting11,Gao Feng11,Frasier Mark12,Chahine Lana M.13ORCID,Coffey Christopher S.14,Singleton Andrew B.15,Simuni Tanya16,Weintraub Daniel17ORCID,Seibyl John18,Toga Arthur W.19,Tanner Caroline M.20,Kieburtz Karl21,Marek Kenneth1218,Siderowf Andrew17,Cedarbaum Jesse M.22,Hutten Samantha J.12,Trenkwalder Claudia2,Graham Danielle23

Affiliation:

1. Department of Neurology University Medical Center Goettingen Goettingen Germany

2. Paracelsus‐Elena Klinik Kassel Germany

3. Department of Neuropathology University Medical Center Goettingen Goettingen Germany

4. Department of Neurosciences University of California San Diego, San Diego California USA

5. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis, Indiana USA

6. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Gothenburg Sweden

7. Department of Psychiatry and Neurochemistry Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden

8. Department of Neurodegenerative Disease UCL Institute of Neurology London United Kingdom

9. UK Dementia Research Institute at UCL London United Kingdom

10. Department of Medical Statistics University Medical Center Goettingen Goettingen Germany

11. Biostatistics Biogen, Cambridge Massachusetts USA

12. The Michael J. Fox Foundation for Parkinson's Research New York New York USA

13. Department of Neurology University of Pittsburgh Pittsburgh Pennsylvania USA

14. Department of Biostatistics College of Public Health, University of Iowa Iowa City, Iowa USA

15. Molecular Genetics Section, Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda Maryland USA

16. Parkinson's Disease and Movement Disorders Center Northwestern University Feinberg School of Medicine Chicago Illinois USA

17. Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA

18. Institute for Neurodegenerative Disorders New Haven Connecticut USA

19. Laboratory of Neuro Imaging University of Southern California, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California Los Angeles California USA

20. Department of Neurology University of California San Francisco, San Francisco, California, USA, and Parkinson's Disease Research Education and Clinical Center, San Francisco Veterans Affairs Health Care System San Francisco, California USA

21. Clinical Trials Coordination Center, University of Rochester Medical Center Rochester, New York USA

22. Coeruleus Clinical Sciences LLC Woodbridge Connecticut USA

23. Discovery and Early Development Biomarkers Biogen, Cambridge Massachusetts USA

Funder

AbbVie

Avid Radiopharmaceuticals

Biogen Idec

Bristol-Myers Squibb

GE Healthcare

Genentech

GlaxoSmithKline

H. Lundbeck A/S

Merck

Michael J. Fox Foundation for Parkinson's Research

Pfizer

UCB

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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