Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

Author:

Bridel Claire1,van Wieringen Wessel N.23,Zetterberg Henrik4567,Tijms Betty M.8,Teunissen Charlotte E.1,Alvarez-Cermeño José C.9,Andreasson Ulf4,Axelsson Markus5,Bäckström David C.10,Bartos Ales1112,Bjerke Maria13,Blennow Kaj45,Boxer Adam14,Brundin Lou1516,Burman Joachim17,Christensen Tove18,Fialová Lenká1920,Forsgren Lars10,Frederiksen Jette L.21,Gisslén Magnus22,Gray Elizabeth23,Gunnarsson Martin24,Hall Sara2526,Hansson Oskar2526,Herbert Megan K.2728,Jakobsson Joel5,Jessen-Krut Jan22,Janelidze Shorena2526,Johannsson Gudmundur2728,Jonsson Michael5,Kappos Ludwig29,Khademi Mohsen1516,Khalil Michael30,Kuhle Jens29,Landén Mikael5,Leinonen Ville3132,Logroscino Giancarlo33,Lu Ching-Hua3435,Lycke Jan5,Magdalinou Nadia K.36,Malaspina Andrea34373839,Mattsson Niklas2526,Meeter Lieke H.4041,Mehta Sanjay R.42,Modvig Signe43,Olsson Tomas1516,Paterson Ross W.44,Pérez-Santiago Josué45,Piehl Fredrik1516,Pijnenburg Yolande A. L.8,Pyykkö Okko T.3132,Ragnarsson Oskar24,Rojas Julio C.14,Romme Christensen Jeppe21,Sandberg Linda10,Scherling Carole S.46,Schott Jonathan M.44,Sellebjerg Finn T.21,Simone Isabella L.4748,Skillbäck Tobias5,Stilund Morten18,Sundström Peter10,Svenningsson Anders49,Tortelli Rosanna3350,Tortorella Carla47,Trentini Alessandro51,Troiano Maria47,Turner Martin R.23,van Swieten John C.40,Vågberg Mattias10,Verbeek Marcel M.5253,Villar Luisa M.54,Visser Pieter Jelle855,Wallin Anders5,Weiss Andreas56,Wikkelsø Carsten5,Wild Edward J.57,

Affiliation:

1. Neurochemistry Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands

2. Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands

3. Department of Mathematics, VU University, Amsterdam, the Netherlands

4. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

5. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

6. Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom

7. Dementia Research Institute at UCL, London, United Kingdom

8. Department of Neurology and Alzheimer Centre, VU University Medical Centre, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands

9. Multiple Sclerosis Unit, Ramon y Cajal University Hospital, Madrid, Spain

10. Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden

11. Third Faculty of Medicine, Department of Neurology, Charles University and General University Hospital, Prague, Czech Republic

12. National Institute of Mental Health, Klecany, Czech Republic

13. Department of Biomedical Sciences, Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born Bunge, University of Antwerp, Antwerp, Belgium

14. Memory and Aging Center, Department of Neurology, University of California, San Francisco

15. Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden

16. Department of Neurology, Karolinska University Hospital Stockholm, Sweden

17. Department of Neuroscience, Uppsala University, Uppsala, Sweden

18. Department of Biomedicine, Aarhus University, Aarhus, Denmark

19. First Faculty of Medicine, Institute of Medical Biochemistry, Prague, Czech Republic

20. Laboratory Diagnostics, Charles University and General University Hospital, Prague, Czech Republic

21. Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

22. Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

23. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

24. Department of Neurology, Faculty of Medicine and Health, Orebro University Hospital, Orebro, Sweden

25. Clinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden

26. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden

27. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg

28. Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden

29. Department of Medicine, University Hospital and University of Basel, Basel, Switzerland

30. Department of Neurology, Medical University of Graz, Graz, Austria

31. Institute of Clinical Medicine, Neurosurgery, University of Eastern Finland, Kuopio

32. Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland

33. Unit of Neurodegenerative Diseases, Department of Clinical Research in Neurology, University of Bari, Bari, Italy

34. North-East London and Essex MND Care Centre, Neuroscience and Trauma Centre, Blizard, United Kingdom

35. Department of Neurology, China Medical University Hospital, Taichung City, Taiwan

36. Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, Queen Square, London, United Kingdom

37. Institute of Cell and Molecular Medicine, Barts, United Kingdom

38. London School of Medicine and Dentistry, Barts, United Kingdom

39. Barts Health NHS Trust, Barts, United Kingdom

40. Alzheimer Centre and Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands

41. Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands

42. Division of Infectious Diseases, University of California, San Diego

43. Department of Clinical Immunology, Copenhagen University Hospital, Righospitalet, Copenhagen, Denmark

44. Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, United Kingdom

45. Puerto Rico OMICS Centre, University of Puerto Rico Comprehensive Cancer Centre, San Juan

46. Department of Psychological Science and Neuroscience Program, Belmont University, Nashville, Tennessee

47. Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy

48. San Camillo Forlanini Hospital, Rome, Italy

49. Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden

50. Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy

51. Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Ferrara, Italy

52. Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Department of Neurology, Nijmegen, the Netherlands

53. Department of Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, the Netherlands

54. Immunology Department, Ramon y Cajal University Hospital, Madrid, Spain

55. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands

56. Evotec AG, Manfred Eigen Campus, Hamburg, Germany

57. UCL Institute of Neurology, Queen Square, London, United Kingdom

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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