N-terminal or signal peptide sequence engineering prevents truncation of human monoclonal antibody light chains
Author:
Affiliation:
1. Department of Biopharmaceutical Development; MedImmune; Milstein Building, Granta Park Cambridge CB21 6GH United Kingdom
2. Lonza Biologics Plc; Slough Berkshire United Kingdom
3. Bayer; Milan Italy
4. Ipsen; Wrexham United Kingdom
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/bit.26301/fullpdf
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3. Characterization of therapeutic antibodies and related products;Beck;Anal Chem,2013
4. Flanking signal and mature peptide residues influence signal peptide cleavage;Choo;BMC Bioinformatics,2008
5. A high-yielding CHO transient system: Coexpression of genes encoding EBNA-1 and GS enhances transient protein expression;Daramola;Biotechnol Prog,2014
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