Plasma Pharmacokinetics of Veledimex, a Small-Molecule Activator Ligand for a Proprietary Gene Therapy Promoter System, in Healthy Subjects

Author:

Cai Hongliang1,Sun Lei1,Miao John1,Krishman Suma2,Lebel Francois1,Barrett John A.1

Affiliation:

1. ZIOPHARM Oncology Inc.; Boston MA USA

2. INTREXON Corporation; Germantown MD USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference35 articles.

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3. Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response;Gollob;Clin Cancer Res,2000

4. Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma;Lenzi;J Transl Med,2007

5. Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma;Alatrash;J Clin Oncol.,2004

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