Discovery and biological evaluation of novel G protein‐coupled receptor 119 agonists for type 2 diabetes
Author:
Affiliation:
1. School of Pharmaceutical ScienceJiangnan UniversityWuxiChina
2. Department of Medicinal Chemistry, School of PharmacyChina Pharmaceutical UniversityNanjingChina
Funder
National Natural Science Foundation of China
Publisher
Wiley
Subject
Drug Discovery,Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.201800267
Reference21 articles.
1. G protein-coupled receptors as targets for anti-diabetic therapeutics
2. G-Protein Coupled Receptors (GPCRs): A Comprehensive Computational Perspective
3. G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges
4. 2,5-Disubstituted pyridines as potent GPR119 agonists
5. Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one
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1. GPR119 agonists: Novel therapeutic agents for type 2 diabetes mellitus;Bioorganic Chemistry;2021-08
2. Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease;Cellular & Molecular Biology Letters;2021-07-07
3. 1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats;Pharmacology;2021
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