2,5-Disubstituted pyridines as potent GPR119 agonists-Reference-Cited by-同舟云学术

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2,5-Disubstituted pyridines as potent GPR119 agonists

Published:2010-04 Issue:8 Volume:20 Page:2577-2581
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wu Yulin,Kuntz Judith D.,Carpenter Andrew J.,Fang Jing,Sauls Howard R.,Gomez Daniel J.,Ammala Carina,Xu Yun,Hart Shane,Tadepalli Sarva

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

2. Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells

3. A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

4. A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

5. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism;Journal of Saudi Chemical Society;2019-12

2. Discovery and biological evaluation of novel G protein‐coupled receptor 119 agonists for type 2 diabetes;Archiv der Pharmazie;2019-02-10

3. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl)pyridine derivatives as GPR119 agonists;Chemical Biology & Drug Design;2018-09-12

4. Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity;Molecular Diversity;2017-06-27

5. On the nonadditivity of the substituent effect in homo-disubstituted pyridines;Journal of Physical Organic Chemistry;2016-10-03

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