Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors-Reference-Cited by-同舟云学术

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors

Published:2018-04-14 Issue:5 Volume:351 Page:1800018
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch. Pharm. Chem. Life Sci.

Author:

El-Sharkawy Lina Y.¹,El-Sakhawy Rowaida A.¹,Abdel-Halim Mohammad¹,Lee Kevin²,Piazza Gary A.²,Ducho Christian³,Hartmann Rolf W.⁴,Abadi Ashraf H.¹^ORCID

Affiliation:

1. Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry; German University in Cairo; Cairo Egypt

2. Drug Discovery Research Center, Mitchell Cancer Institute; University of South Alabama; Mobile Alabama USA

3. Department of Pharmacy, Pharmaceutical and Medicinal Chemistry; Saarland University; Saarbrücken Germany

4. Department of Drug Design and Optimization; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Saarbrücken Germany

Funder

National Cancer Institute

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Reference30 articles.

1. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

2. Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)

3. Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

4. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

5. Phosphodiesterase inhibitors and the eye

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