Affiliation:
1. Department of Chemistry, Telangana University, Dichpally, Nizamabad, 503322, TS, India
Abstract
Abstract:
Our primary research objective is to create and formulate small ring heterocycles with enhanced
biological efficacy. Amide functionalized trifluoromethyl thieno[2,3-b]pyridine derivatives as
a series were prepared starting from reaction between 1,3 di-ketone and thiocyanoacetamide and obtained
pyridine 3. Compound 3 reacts with bromoethyl acetate and obtained compound 4, further
compound 4 on reaction with diverse substituted aromatic and aliphatic amines to get amide derivatives
5a-d, 6a-d and 7a-h. All the final compounds evaluated for anti cancer activity against four
human cancer cell lines such as ‘HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-
222); HepG2 - Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22)’ and promising compounds
7d, 7e and 7f have been identified. For compounds 7d, 7e and 7f molecular docking interactions have
been identified.
Publisher
Bentham Science Publishers Ltd.
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