Pharmacokinetic and Pharmacodynamic Modeling Analysis of Intravenous Esomeprazole in Healthy Volunteers

Author:

Liu Dongyang1,Yang Hong2,Jiang Ji1,Nagy Péter3,Shen Kai1,Qian Jiaming2,Hu Pei1

Affiliation:

1. Clinical Pharmacology Research Center, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences; Beijing China

2. Department of Gastroenterology; Peking Union Medical College Hospital and Chinese Academy of Medical Sciences; Beijing China

3. AstraZeneca R&D; Mölndal Sweden

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference44 articles.

1. Review article: the clinical pharmacology of proton pump inhibitors;Sachs;Aliment Pharmacol Ther,2006

2. Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole;Andersson;Aliment Pharmacol Ther,2001

3. FDA. Label for Nexium 2014 http://www.accessdata.fda.gov/scripts/cder/drugsatfda/

4. FDA. Label for Nexium IV 2014 http://www.accessdata.fda.gov/scripts/cder/drugsatfda/

5. A pharmacokinetic study comparing single and repeated oral doses of 20 mg and 40 mg omeprazole and its two optical isomers, S-omeprazole (esomeprazole) and R-omeprazole, in healthy subjects;Hassan-Alin;Eur J Clin Pharmacol,2005

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