A pharmacokinetic study comparing single and repeated oral doses of 20�mg and 40�mg omeprazole and its two optical isomers, S-omeprazole (esomeprazole) and R-omeprazole, in healthy subjects

Author:

Hassan-Alin M.,Andersson T.,Niazi M.,R�hss K.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference15 articles.

1. AstraZeneca, Data on File

2. Äbelö A, Andersson TB, Antonsson M, Naudot AK, Skånberg I, Weidolf L (2000) Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 28:96?972

3. Andersson T, Bredberg E, Sunzel M, Antonsson M, Weidolf L (2000) Pharmacokinetics (PK) and effect on pentagastrin stimulated peak acid output (PAO) of omeprazole and its 2 optical isomers, S-omeprazole/esomeprazole (E) and R-omeprazole (RO). Gastroenterology 118(4 Pt II):A1210

4. Andersson T, Hassan-Alin M, Hasselgren G, Röhss K, Weidolf L (2001) Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 40(6):411?426

5. Lagerström PO, Persson BA (1984) Determination of omeprazole and metabolites in plasma and urine by liquid chromatography. J Chromatogr 309:347?356

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