BRIM-P: A phase I, open-label, multicenter, dose-escalation study of vemurafenib in pediatric patients with surgically incurable, BRAF mutation-positive melanoma

Author:

Chisholm Julia C.1ORCID,Suvada Jozef2,Dunkel Ira J.3,Casanova Michela4,Zhang Weijiang5,Ritchie Natasha6,Choi YounJeong7,Park Jane7,Das Thakur Meghna7,Simko Stephen7,Wan Rachel Tam Nga7,Ferrari Andrea4ORCID

Affiliation:

1. Children and Young People's Unit; The Royal Marsden NHS Foundation Trust; Sutton UK

2. Department of Pediatric Hematology and Oncology; Children's Teaching Hospital and St. Elizabeth University; Bratislava Slovakia

3. Memorial Sloan Kettering Cancer Center; New York New York

4. Fondazione IRCCS Istituto Nazionale dei Tumori; Milan Italy

5. Roche Innovation Center; New York New York

6. Roche Products Limited; Welwyn Garden City UK

7. Genentech; South San Francisco California

Funder

F. Hoffmann-La Roche

National Institutes of Health

NCI Cancer Center

National Health Service

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference42 articles.

1. Ferlay J Soerjomataram I Ervik M GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.11. Lyon, France 2013 http://globocan.iarc.fr

2. Pediatric melanoma: Risk factor and survival analysis of the surveillance, epidemiology and end results database;Strouse;J Clin Oncol,2005

3. The feasibility of adjuvant interferon alpha-2b in children with high-risk melanoma;Navid;Cancer,2005

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