Metabolite profiling of IMID‐2, a novel anticancer molecule of piperazine derivative: In silico prediction, in vitro and in vivo metabolite characterization using UPLC–QTOF

Metabolite profiling of IMID‐2, a novel anticancer molecule of piperazine derivative: In silico prediction, in vitro and in vivo metabolite characterization using UPLC–QTOF–MS/MS

Published:2021-02-14 Issue:6 Volume:35 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Panday Niraj Kumar¹²^ORCID,Thakkar Disha¹²,Patel Sagarkumar¹³,Shard Amit¹³^ORCID,Sengupta Pinaki¹²^ORCID

Affiliation:

1. National Institute of Pharmaceutical Education and Research—Ahmedabad An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Airforce Station, Palaj Gandhinagar Gujarat India

2. Department of Pharmaceutical Analysis India

3. Department of Medicinal Chemistry India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.5082

Reference32 articles.

1. Synthesis and Biological Activity of Piperazine Derivatives of Phenothiazine

2. Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents

3. Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2;Babu M. S.;PLoS One,2018