Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors-Reference-Cited by-同舟云学术

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Published:2017-11-21 Issue:12 Volume:8 Page:1292-1297
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bungard Christopher J.¹^ORCID,Williams Peter D.¹,Schulz Jurgen¹,Wiscount Catherine M.¹,Holloway M. Katharine¹,Loughran H. Marie¹,Manikowski Jesse J.¹,Su Hua-Poo¹,Bennett David J.¹,Chang Lehua²,Chu Xin-Jie²,Crespo Alejandro²,Dwyer Michael P.²,Keertikar Kartik²,Morriello Gregori J.²,Stamford Andrew W.²,Waddell Sherman T.²,Zhong Bin³,Hu Bin³,Ji Tao³,Diamond Tracy L.¹,Bahnck-Teets Carolyn¹,Carroll Steven S.¹,Fay John F.¹,Min Xu¹,Morris William²^ORCID,Ballard Jeanine E.¹,Miller Michael D.¹,McCauley John A.¹

Affiliation:

1. Merck & Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, United States

2. Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

3. WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00386

Reference17 articles.

1. Cleavage of HIV-1gagPolyprotein Synthesized In Vitro: Sequential Cleavage by the Viral Protease