Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children

Author:

Hornik Christoph P.1,Gonzalez Daniel2,van den Anker John3,Atz Andrew M.4,Yogev Ram5,Poindexter Brenda B.6,Ng Kee Chong7,Delmore Paula8,Harper Barrie L.1,Melloni Chiara1,Lewandowski Andrew9,Gelber Casey9,Cohen-Wolkowiez Michael1,Lee Jan Hau7,

Affiliation:

1. Duke Clinical Research Institute; Duke University School of Medicine; Durham NC USA

2. Division of Pharmacotherapy and Experimental Therapeutics; UNC Eshelman School of Pharmacy; University of North Carolina; Chapel Hill NC USA

3. Children's National Medical Center; Washington DC USA

4. Medical University of South Carolina Children's Hospital; Charleston SC USA

5. Ann and Robert H. Lurie Children's Hospital of Chicago; Chicago IL USA

6. Cincinnati Children's Hospital; Cincinnati OH USA

7. KK Women's and Children's Hospital; Singapore

8. Wesley Medical Center; Wichita KS USA

9. The EMMES Corporation; Rockville MD USA

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Biomedical Advanced Research and Development Authority

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference50 articles.

1. Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures;Brunette;Paediatr Anaesth,2011

2. Procedural sedation outside of the operating room using ketamine in 22,645 children: a report from the Pediatric Sedation Research Consortium;Grunwell;Pediatr Crit Care Med,2016

3. US National Library of Medicine DailyMed. Label: ketamine hydrochloride-ketamine hydrochloride injection https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid = 14b54219-f5fd-42fa-8784-719f9785497f&audience = professional 2017

4. Respiratory adverse events during upper digestive endoscopies in children under ketamine sedation;Flores-Gonzalez;Minerva Pediatr

5. Changes in blood pressure and heart rate during sedation with ketamine in the pediatric ED;Patterson;Am J Emerg Med,2017

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