The importance of ketamine for cerebral protection in pediatric cardiac surgery

Author:

Ivkin A. A.1ORCID,Grigoriev E. V.1ORCID

Affiliation:

1. Research Institute for Complex Problems of Cardiovascular Diseases

Abstract

The problem of cerebral protection in cardiac surgery is relevant, despite all the techniques used. Due to its properties, ketamine can occupy its niche in solving this problem. The article analyzes current literature sources and describes the use of ketamine for analgesia, sedation and cerebral protection, and analyzes its properties for reducing the systemic inflammatory response. The mechanisms of its action and recommended doses are given, and schemes for its use both during anesthesia and the postoperative period are presented.

Publisher

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Reference50 articles.

1. Ivkin A.A., Borisenko D.V., Tsepokina A.V. et al. Renouncement of red blood cells for heart-lung machine filling for perioperative prevention of cerebral injury in children undergoing cardiac surgery. Russian Journal of Anesthesiology and Reanimatology, 2021, no. 4, pp. 54‒61. (In Russ.) DOI: 10.17116/anaesthesiology202104154.

2. Borisenko D., Ivkin A., Shukevich D., Kornelyuk R. The Effect of erythrocyte- containing donor blood components in the priming of the cardiopulmonary bypass circuit on the development of systemic inflammation during correction of congenital heart defects in children. General Reanimatology, 2022, vol. 18, no. 3, pp. 30‒37. (In Russ. and Engl.) DOI: 10.15360/1813-9779-2022-3-30-37.

3. Abdelhalim A. A., Alarfaj A. M. The effect of ketamine versus fentanyl on the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients undergoing tonsillectomy with or without adenoidectomy // Saudi J Anaesth. – 2013. – Vol. 7, № 4. – P. 392‒398. DOI: 10.4103/1658-354X.121047.

4. Alanazi E. The effectiveness of ketamine compared to opioid analgesics for management of acute pain in children in the emergency department: systematic review // Am J Emerg Med. – 2022. – Vol. 61. – P. 143‒151. DOI: 10.1016/j.ajem.2022.08.004.

5. Bhutta A. T., Schmitz M. L., Swearingen C. et al. Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial // Pediatr Crit Care Med. – 2012. – Vol. 13, № 3. – P. 328‒337. DOI: 10.1097/PCC.0b013e31822f18f9.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3