Parameterization of metabolite and macromolecule contributions in interrelated MR spectra of human brain using multidimensional modeling

Author:

Hoefemann Maike12,Bolliger Christine Sandra13,Chong Daniel G.Q.12,Veen Jan Willem4,Kreis Roland1ORCID

Affiliation:

1. Departments of Radiology and Biomedical ResearchUniversity of Bern Bern Switzerland

2. Graduate School for Cellular and Biomedical SciencesUniversity of Bern Bern Switzerland

3. Bruker BioSpin AG Fällanden Switzerland

4. NIH, NIMH, Magnetic Resonance Spectroscopy Core Bethesda Maryland US

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Spectroscopy,Radiology, Nuclear Medicine and imaging,Molecular Medicine

Reference32 articles.

1. Methodological consensus on clinical proton MRS of the brain: Review and recommendations

2. Clinical Proton MR Spectroscopy in Central Nervous System Disorders

3. Two-dimensional linear-combination model fitting of magnetic resonance spectra to define the macromolecule baseline using FiTAID, a Fitting Tool for Arrays of Interrelated Datasets

4. BolligerCS ChongDG SlotboomJ BoeschC KreisR.Modeling of 3‐dimensional MR spectra of human brain: Simultaneous determination of T1 T2 and concentrations based on combined 2DJ inversion‐recovery spectroscopy. In:Proceedings of the 18th scientific meeting of ISMRM and ESMRMB.Stockholm Sweden;2010:3325.

5. Simultaneous determination of metabolite concentrations, T 1 and T 2 relaxation times

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