Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS

Author:

Burckhardt Bjoern B.1,Tins Jutta1,Laeer Stephanie1

Affiliation:

1. Institute of Clinical Pharmacy and Pharmacotherapy; Heinrich-Heine-University; Duesseldorf Germany

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference24 articles.

1. Simultaneous determination of aliskiren and hydrochlorothiazide in tablets and spiked human urine by ion-pair liquid chromatography;Belal;Pharmazie,2013

2. Determination of aliskiren in human serum quantities by HPLC-tandem mass spectrometry appropriate for pediatric trials;Burckhardt;Biomedical Chromatography,2013

3. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses;Chambers;Journal of Chromatography B,2007

4. CHMP (EMA) Product information aliskiren. Summary of product characteristics 2012 http://www.emea.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000780/WC500047010.pdf

5. European Medicines Agency Guideline on bioanalytical method validation: EMEA/CHMP/EWP/192217/2009 2012 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

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