Effect of moxifloxacin on pharmacokinetics of enalapril in rats

Abstract

The purpose of this study was to investigate the effect of moxifloxacin on the pharmacokinetics of enalapril. Single administration experiment: 12 Wistar rats were randomly divided into two groups on average. Control group: enalapril (15mg/kg)+ normal saline combined group: enalapril (15mg/kg)+ moxifloxacin (80mg/kg), intragastric administration. Blood samples were measured by LC-MS/MS. Multiple administration experiment: 12 Wistar rats were randomly divided into two groups on average. The control group was given normal saline (day1-7)+ enalapril (day8,15mg/kg), and the combination group was given moxifloxacin (day1-7, 80mg/kg)+ enalapril (day8,15mg/kg) by intra-gastric administration. The treatments were the same as above. Pharmacokinetics parameters were calculated using Winnonlin 6.1 software and the two groups were compared using SPSS18.0 software. In single administration experiment compared with the control group, the AUC(0-t) and Cmax of enalapril were decreased by 31.99%（P<0.05), 42.57% (P<0.05) in the combined administration group. Quinolone antibiotics and ACEI drugs should not be taken at the same time during clinical treatment to avoid drug interactions that may occur when combined drugs are used.