A doubly auxotrophic CHO‐K1 cell line for the production of recombinant monoclonal antibodies
Author:
Affiliation:
1. Department of Biological SciencesColumbia University New York New York
2. Cell Line Development, Biologics Process Development & Clinical ManufacturingMerck & Co., Inc. Kenilworth New Jersey
Funder
Merck
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27367
Reference17 articles.
1. Comparison of three transposons for the generation of highly productive recombinant CHO cell pools and cell lines
2. CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation
3. A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
4. Evaluation of the OSCAR™ system for the production of monoclonal antibodies by CHO-K1 cells
5. The art of CHO cell engineering: A comprehensive retrospect and future perspectives
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