Pharmacokinetics and Pharmacodynamics of Anacetrapib Following Single Doses in Healthy, Young Japanese and White Male Subjects

Author:

Krishna Rajesh1,Gheyas Ferdous1,Liu Yang1,Cote Josee1,Laterza Omar1,Ruckle Jon L.23,Wagner John A.14,Denker Andrew E.15

Affiliation:

1. MRL; Merck & Co. Inc.; Kenilworth NJ USA

2. Covance Clinical Research Unit; Inc. (formerly known as Radiant Research - Honolulu); Honolulu HI USA

3. Current Address: Pacific Pharma Group, LLC; Tacoma WA USA

4. Current Address: Takeda Pharmaceuticals International Co.; Cambridge MA USA

5. Current Address: Alexion Pharmaceuticals; New Haven CT USA

Funder

Merck

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference26 articles.

1. Plasma cholesteryl ester transfer protein;Tall;J. Lipid Res.,1993

2. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects;Millar;J Clin Invest,2015

3. Cholesteryl ester transfer protein inhibition with anacetrapib decreases fractional clearance rates of high-density lipoprotein apolipoprotein A-I and plasma cholesteryl ester transfer protein;Reyes-Soffer;Arterioscler Thromb Vasc Biol.,2016

4. Landray MJ Clinical effects of anacetrapib in people with established vascular disease: results of the Randomized EValuation of the Effects of Anacetrapib through Lipid Modification [abstract] European Society of Cardiology Annual Meeting 2017

5. Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with dyslipidemia;Teramoto;Atherosclerosis,2013

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