TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

Author:

Hong Shengjun1,Dobricic Valerija1,Ohlei Olena1,Bos Isabelle23,Vos Stephanie J. B.23,Prokopenko Dmitry4,Tijms Betty M.3,Andreasson Ulf56,Blennow Kaj56,Vandenberghe Rik78,Gabel Silvy7,Scheltens Philip3,Teunissen Charlotte E.9,Engelborghs Sebastiaan1011,Frisoni Giovanni1213,Blin Olivier14,Richardson Jill C.15,Bordet Regis16,Lleó Alberto17,Alcolea Daniel17,Popp Julius1819,Clark Christopher18,Peyratout Gwendoline19,Martinez‐Lage Pablo20,Tainta Mikel20,Dobson Richard J. B.2122232425,Legido‐Quigley Cristina26,Sleegers Kristel2728,Van Broeckhoven Christine2728,Tanzi Rudolph E.4,ten Kate Mara2930,Wittig Michael31,Franke Andre31,Lill Christina M.132,Barkhof Frederik33,Lovestone Simon34,Streffer Johannes3536,Zetterberg Henrik563738,Visser Pieter Jelle2339,Bertram Lars140,

Affiliation:

1. Lübeck Interdisciplinary Platform for Genome Analytics (LIGA) University of Lübeck Lübeck Germany

2. Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Alzheimer Centrum Limburg Maastricht University Maastricht the Netherlands

3. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC the Netherlands

4. Genetics and Aging Unit and McCance Center for Brain Health Department of Neurology Massachusetts General Hospital Boston Massachusetts USA

5. Institute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

6. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

7. Laboratory for Cognitive Neurology Department of Neurosciences, KU Leuven Leuven Belgium

8. Neurology Service University Hospital Leuven Leuven Belgium

9. Neurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam University Medical Centers, Vrije Universiteit Amsterdam the Netherlands

10. Department of Biomedical Sciences Institute Born‐Bunge University of Antwerp Antwerp Belgium

11. Department of Neurology and Center for Neurosciences UZ Brussel and Vrije Universiteit Brussel (VUB) Brussels Belgium

12. University of Geneva Geneva Switzerland

13. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

14. AIX Marseille University, INS, Ap‐hm Marseille France

15. Neurosciences Therapeutic Area GlaxoSmithKline R&D Stevenage UK

16. Inserm CHU Lille University of Lille Lille France

17. Memory Unit Neurology Department. Hospital de Sant Pau Barcelona and Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED) Madrid Spain

18. Centre for Gerontopsychiatric Medicine Department of Geriatric Psychiatry University Hospital of Psychiatry Zurich Zürich Switzerland

19. Old Age Psychiatry Department of Psychiatry University Hospital of Lausanne Lausanne Switzerland

20. Department of Neurology Center for Research and Advanced Therapies CITA‐Alzheimer Foundation San Sebastian Spain

21. Department of Biostatistics and Health Informatics Institute of Psychiatry Psychology and Neuroscience, King's College London London UK

22. NIHR BioResource Centre Maudsley NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London London UK

23. Health Data Research UK London University College London London UK

24. Institute of Health Informatics University College London London UK

25. The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK

26. Steno Diabetes Center Copenhagen Denmark and Institute of Pharmaceutical Sciences, King's College London London UK

27. Neurodegenerative Brain Diseases Group Center for Molecular Neurology, VIB Antwerp Belgium

28. Department of Biomedical Sciences University of Antwerp Antwerp Belgium

29. Alzheimer Center and Department of Neurology Amsterdam University Medical Centers, Amsterdam Neuroscience Amsterdam the Netherlands

30. Department of Radiology and Nuclear Medicine Amsterdam University Medical Centers Amsterdam Neuroscience Amsterdam the Netherlands

31. Institute of Clinical Molecular Biology Christian‐Albrechts‐University of Kiel Kiel Germany

32. Ageing Epidemiology Research Unit School of Public Health Imperial College London United Kingdom

33. Institutes of Neurology and Healthcare Engineering University College London London UK

34. Department of Psychiatry University of Oxford Oxford UK

35. Reference Center for Biological Markers of Dementia (BIODEM) Institute Born‐Bunge University of Antwerp Antwerp Belgium

36. Translational Medicine Neuroscience UCB Biopharma SPRL Braine l'Alleud Belgium

37. Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology Queen Square London UK

38. UK Dementia Research Institute at UCL London UK

39. Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Karolinska Instutet Stockholm Sweden

40. Department of Psychology University of Oslo Oslo Norway

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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