Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development
Author:
Affiliation:
1. Axcella Therapeutics Cambridge Massachusetts USA
2. Critical Path Institute Tucson Arizona USA
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12801
Reference26 articles.
1. Extrapolation of Efficacy in Pediatric Drug Development and Evidence-based Medicine: Progress and Lessons Learned
2. Paediatric extrapolation: the panacea for paediatric drug development?
3. A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis
4. Evaluation of a mathematical model of diabetes progression against observations in the Diabetes Prevention Program
5. Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model
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