Delineating gene–environment effects using virtual twins of patients treated with clozapine-Reference-Cited by-同舟云学术

Delineating gene–environment effects using virtual twins of patients treated with clozapine

Published:2022-11-24 Issue:2 Volume:12 Page:168-179
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacom & Syst Pharma

Author:

Mostafa Sam¹²,Polasek Thomas M.¹³⁴,Bousman Chad⁵⁶⁷⁸⁹,Rostami‐Hodjegan Amin¹⁰¹¹^ORCID,Sheffield Leslie J.²,Everall Ian⁵⁶¹²¹³,Pantelis Christos⁵⁶¹³,Kirkpatrick Carl M. J.¹

Affiliation:

1. Centre for Medicine Use and Safety Monash University Victoria Parkville Australia

2. MyDNA Life Australia Limited Victoria South Yarra Australia

3. Certara New Jersey Princeton USA

4. Department of Clinical Pharmacology Royal Adelaide Hospital South Australia Adelaide Australia

5. Melbourne Neuropsychiatry Centre, Department of Psychiatry University of Melbourne & Melbourne Health Victoria Melbourne Australia

6. The Cooperative Research Centre (CRC) for Mental Health Victoria Melbourne Australia

7. Alberta Children's Hospital Research Institute, Cumming School of Medicine University of Calgary Alberta Calgary Canada

8. Hotchkiss Brain Institute, Cumming School of Medicine University of Calgary Alberta Calgary Canada

9. Departments of Medical Genetics, Psychiatry, and Physiology and Pharmacology University of Calgary Alberta Calgary Canada

10. Centre for Applied Pharmacokinetic Research (CAPKR), School of Health Sciences University of Manchester Manchester UK

11. Simcyp Division Certara UK Limited Sheffield UK

12. Western Australian Health Translation Network Nedlands Western Australia Australia

13. Florey Institute of Neuroscience and Mental Health University of Melbourne Victoria Melbourne Australia

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12886

Reference42 articles.

1. Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling

2. Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio

3. Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

4. Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing

5. Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Drug Exposure

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