Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing-Reference-Cited by-同舟云学术

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Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing

Published:2020-02-14 Issue:4 Volume:107 Page:742-745
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Polasek Thomas M.¹²³,Rostami‐Hodjegan Amin¹⁴

Affiliation:

1. Certara Princeton New Jersey USA

2. Department of Clinical Pharmacology Royal Adelaide Hospital Adelaide Australia

3. Centre for Medicines Use and Safety Monash University Melbourne Australia

4. Centre for Applied Pharmacokinetic Research University of Manchester Manchester UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1778

Reference10 articles.

1. Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

2. Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram

3. Influence of OCT 1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study

4. Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

5. Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

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