Oxidative degradation profile studies of tavaborole by a validated stability indicating RP‐UPLC method: Isolation and characterization of novel degradant using 2D‐NMR and HRMS-Reference-Cited by-同舟云学术

Oxidative degradation profile studies of tavaborole by a validated stability indicating RP‐UPLC method: Isolation and characterization of novel degradant using 2D‐NMR and HRMS

Published:2021-01-25 Issue:6 Volume:35 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Puppala Umamaheshwar¹²^ORCID,Marisetti Vishnu Murthy³,Srinivas Koduri S. V.¹,Reddy K. Venkateshwara⁴,Kaliyaperumal Muralidharan¹,Doddipalla Raju¹

Affiliation:

1. Analytical Research and Development Laboratory, GVK Biosciences Private Limited, No. 28A, IDA Nacharam Hyderabad Telangana India

2. Department of Chemistry JNTU Hyderabad Hyderabad India

3. Analytical Research and Development, ScieGen Pharmaceuticals Inc, Hauppauge New York USA

4. CMR Engineering College Hyderabad India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.5070

Reference19 articles.

1. The role of degradant profiling in active pharmaceutical ingredients and drug products☆

2. Tavaborole, a Novel Boron-Containing Small Molecule for the Topical Treatment of Onychomycosis, Is Noncarcinogenic in 2-Year Carcinogenicity Studies

3. Tavaborole, a Novel Boron-Containing Small Molecule Pharmaceutical Agent for Topical Treatment of Onychomycosis

4. In vitro nail penetration and antifungal activity of tavaborole, a boron‐based pharmaceutical;Coronado D.;Journal of Drugs in Dermatology,2015

5. Drug impurity profiling strategies*1

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4. Oxidative degradation profile studies of tavaborole by a validated stability indicating RP‐UPLC method: Isolation and characterization of novel degradant using 2D‐NMR and HRMS;Biomedical Chromatography;2021-01-25