Structure and modeling in the design of β- and γ-secretase inhibitors
Author:
Publisher
Wiley
Subject
Drug Discovery
Reference186 articles.
1. An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes;Albert;Curr Top Med Chem,2007
2. A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures;Annis;J Am Chem Soc,2004
3. The linear interaction energy method for predicting ligand binding free energies;Åqvist;Comb Chem High Throughput Screen,2001
4. Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors;Asberom;Bioorg Med Chem Lett,2007
5. Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease;Asberom;Bioorg Med Chem Lett,2007
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