1. Mouse Genome Engineering Core Facility, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center Omaha Nebraska
2. These authors contributed equally to this work
3. National Centre for Biotechnology (CNB‐CSIC) Madrid Spain
4. CIBERER‐ISCIII Madrid Spain
5. Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine Kanagawa Japan
6. Department of Bioproduction, Tokyo University of Agriculture Hokkaido Japan
7. These authors are co‐corresponding authors