1. Laboratory of Innovative NanomedicineFaculty of Pharmaceutical SciencesHokkaido University Kita‐12, Nishi‐6, Kita‐ku Sapporo Hokkaido 060‐0812 Japan
2. Department of PharmaceuticsFaculty of PharmacyAssiut University Assiut 71526 Egypt
3. Department of Histology and CytologyFaculty of Veterinary MedicineZagazig University Zagazig 44511 Egypt
4. Laboratory of AnatomyDepartment of Biomedical SciencesGraduate School of Veterinary MedicineHokkaido University Kita 18, Nishi 9, Kita‐ku Sapporo 060‐0818 Japan
5. Formulation Research Lab.Taiho Pharmaceutical Co., Ltd. 224‐2, Ebisuno, Hiraishi, Kawauchi‐cho Tokushima 771‐0194 Japan
6. Laboratory for Molecular Design of PharmaceuticsFaculty of Pharmaceutical SciencesHokkaido University Sapporo Hokkaido 060‐0812 Japan