Characterization of Methyltransferase AlmCII in Chalcomycin Biosynthesis: The First TylF Family O-Methyltransferase Works on a 4′-Deoxysugar-Reference-Cited by-同舟云学术

Characterization of Methyltransferase AlmCII in Chalcomycin Biosynthesis: The First TylF Family O-Methyltransferase Works on a 4′-Deoxysugar

Published:2017-06-28 Issue:15 Volume:18 Page:1510-1517
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Dai Ping¹,Wang Chuan-Xi¹,Gao Hao¹,Wang Qiao-Zhen¹,Tang Xiao-Long¹,Chen Guo-Dong¹,Hong Kui²,Hu Dan¹³,Yao Xin-Sheng¹

Affiliation:

1. Institute of Traditional Chinese Medicine and Natural Products; College of Pharmacy; Jinan University; No. 601 Huangpu Avenue Guangzhou 510632 P. R. China

2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery; Ministry of Education; School of Pharmaceutical Sciences; Wuhan University; No. 185 Donghu Road Wuhan 430071 P. R. China

3. State Key Laboratory of Bioorganic and Natural Products Chemistry; Shanghai Institute of Organic Chemistry; University of Chinese Academy of Sciences; No.345 Lingling Road Shanghai 200032 P. R. China

Funder

National Science Fundation of China

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Metabolic Engineering of Aminocoumarins: Inactivation of the Methyltransferase Gene cloP and Generation of New Clorobiocin Derivatives in a Heterologous Host

2. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.

3. Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis

4. Architectures, mechanisms and molecular evolution of natural product methyltransferases

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