Functional Characterization of a Regiospecific Sugar- <i>O</i> -Methyltransferase from <i>Nocardia</i>-Reference-Cited by-同舟云学术

Functional Characterization of a Regiospecific Sugar- O -Methyltransferase from Nocardia

Published:2022-07-12 Issue:13 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Poudel Purna Bahadur¹,Pandey Ramesh Prasad¹,Dhakal Dipesh¹^ORCID,Kim Tae-Su¹,Nguyen Trang Thi Huyen¹,Jung Hye Jin¹²,Shin Hee Jeong¹,Timalsina Binod³,Sohng Jae Kyung¹²^ORCID

Affiliation:

1. Institute of Biomolecule Reconstruction (iBR), Department of Life Science and Biochemical Engineering, Sun Moon University, Asan-si, Chungnam, Republic of Korea

2. Department of Biotechnology and Pharmaceutical Engineering, Sun Moon University, Asan-si, Chungnam, Republic of Korea

3. Department of Anatomy, Dongguk University College of Medicine, Gyeongju, Republic of Korea

Abstract

ThnM1 is a putative sugar- O -methyltransferase produced by the Nocardia sp. strain CS682 and is encoded by a gene belonging to the biosynthetic gene cluster (BGC) of 1-(α- l -(2- O -methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene. We demonstrated that ThnM1 is a promiscuous enzyme with regiospecific activity at the 2′-OH of rhamnose.

Funder

Rural Development Administration

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00754-22

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