Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin-Reference-Cited by-同舟云学术

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

Published:2015-10-23 Issue:17 Volume:16 Page:2484-2490
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Hirayama Akane¹,Miyanaga Akimasa²,Kudo Fumitaka²,Eguchi Tadashi¹

Affiliation:

1. Department of Chemistry and Materials Science; Tokyo Institute of Technology; 2-12-1 O-okayama Meguro-ku Tokyo 152-8551 Japan

2. Department of Chemistry; Tokyo Institute of Technology; 2-12-1 O-okayama Meguro-ku Tokyo 152-8551 Japan

Funder

Photon Factory Advisory Committee

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology of Japan

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. A Single PLP-Dependent Enzyme PctV Catalyzes the Transformation of 3-Dehydroshikimate into 3-Aminobenzoate in the Biosynthesis of Pactamycin

2. Mutasynthesis of Fluorinated Pactamycin Analogues and Their Antimalarial Activity

3. Direct evidence from multiple carbon-13-labeling and homonuclear decoupling for the labeling pattern by glucose of the m-aminobenzoyl (C7N) unit of pactamycin

4. The biochemistry of heme biosynthesis

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