Improvement of S N Ar Reaction Rate by an Electron‐Withdrawing Group in the Crosslinking of DNA Cytosine‐5 Methyltransferase by a Covalent Oligodeoxyribonucleotide Inhibitor-Reference-Cited by-同舟云学术

Improvement of S N Ar Reaction Rate by an Electron‐Withdrawing Group in the Crosslinking of DNA Cytosine‐5 Methyltransferase by a Covalent Oligodeoxyribonucleotide Inhibitor

Published:2018-07-16 Issue:17 Volume:19 Page:1866-1872
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Kasai Yukiko¹,Sato Kousuke²^ORCID,Utsumi Shohei¹,Ichikawa Satoshi¹³

Affiliation:

1. Faculty of Pharmaceutical SciencesHokkaido University Kita-12, Nishi-6 Kita-ku Sapporo 060-0812 Japan

2. Faculty of Pharmaceutical SciencesHealth SciencesUniversity of Hokkaido 1757 Kanazawa Tobetsu Ishikari-gun 061-0293 Japan

3. Center for Research and Education on Drug DiscoveryHokkaido University Kita-12, Nishi-6 Kita-ku Sapporo 060-0812 Japan

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201800244

Reference50 articles.

2. Primary DNA sequence determines sites of maintenance and de novo methylation by mammalian DNA methyltransferases.

3. Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferase

5. Epigenetics in human disease and prospects for epigenetic therapy

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