Affiliation:
1. Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, UK
Abstract
Abstract
Ischaemia-reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemiareperfusion. Finally, several mechanisms that limit ischaemiareperfusion injury are discussed and a number of novel therapies presented.
Publisher
Oxford University Press (OUP)
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