The effect of intravenous aprotinin (Trasylol) on intraperitoneal adhesion formation in the rat-Reference-Cited by-同舟云学术

The effect of intravenous aprotinin (Trasylol) on intraperitoneal adhesion formation in the rat

Published:1981-01 Issue:1 Volume:68 Page:59-60
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Young Howard L¹,Wheeler Malcolm H¹,Morse David¹

Affiliation:

1. University Department of Surgery, Welsh National School of Medicine, University Hospital of Wales, Heath Park, Cardiff, South Glamorgan

Abstract

Summary A randomized controlled trial to assess the effect of intravenous Trasylol on postoperative intraperitoneal adhesion formation has been performed in rats. Before undergoing a standard left colonic resection, animals received i.v. Trasylol 10 000 KIU. This dose was repeated 8-hourly for 3 days postoperatively. Control animals received saline placebo. The mean percentage circumference of the anastomosis covered with adhesions in the Trasylol group animals was 20.86±6.08 compared with 45.24±5.97 in the control group (P < 0.01). Significantly more animals treated with Trasylol were completely free of adhesions than those receiving saline. Bursting pressures did not differ between the two groups. Intravenous Trasylol clearly inhibits intraperitoneal adhesion formation in this model.

Funder

Bayer (UK) Ltd

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

http://academic.oup.com/bjs/article-pdf/68/1/59/36967199/bjs1800680119.pdf

Reference9 articles.

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3. Noxythiolin and peritoneal adhesion formation;Gilmore;Br. J. Surg.,1976

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