Affiliation:
1. Surgical Professorial Unit, St Bartholomew's Hospital, London
Abstract
Abstract
Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P < 0·02). Noxytiolin reduced both the total and the mean number of adhesions formed (P < 0·2) and their mean length of attachment (P < 0·05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.
Publisher
Oxford University Press (OUP)
Cited by
16 articles.
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