Brain perfusion, cognition, and plasma Alzheimer's biomarkers in moyamoya disease

Author:

Zou Xiang12345,Liao Yujun12345,Jiang Conglin12345,Yuan Yifan15,Zhao Fan12345,Ding Ding567,Chen Liang12345,Xu Bin12345,Mao Ying12345

Affiliation:

1. Department of Neurosurgery Huashan Hospital, Fudan University Shanghai China

2. Neurosurgical Institute of Fudan University Shanghai China

3. Shanghai Clinical Medical Center of Neurosurgery Shanghai China

4. Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration Shanghai China

5. National Center for Neurological Disorders Shanghai China

6. National Clinical Research Center for Aging and Medicine Huashan Hospital Fudan University Shanghai China

7. Institute of Neurology Huashan Hospital Fudan University Shanghai China

Abstract

AbstractINTRODUCTIONBecause growing interest has been focusing on cerebral blood flow (CBF) to predict, prevent, and treat Alzheimer's disease (AD), it is important to clarify the role of CBF in AD pathology and cognitive decline.METHODSIn a moyamoya disease (MMD) cohort, we examined CBF, specific cognitive domains, and plasma AD biomarkers, as well as correlations among these variables.RESULTSCBF was significantly reduced in newly diagnosed MMD patients, while plasma phosphorylated tau181 was elevated and positively correlated with hypoperfusion accumulation. MMD patients scored significantly lower than controls in multiple cognitive tests. Revascularization increased CBF to the recipient brain territories as well as cognitive performance but produced no significant change in AD biomarker levels.DISCUSSIONThese data suggest a link between accumulated reductions in CBF and cognitive decline, as well as a possible role of AD‐like pathological burden. Further studies in MMD will provide opportunities to explore new treatment strategies.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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