Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.-Reference-Cited by-同舟云学术

Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.

Published:2024-03-25 Issue:3-4 Volume:2 Page:
ISSN:2751-4765
Container-title:ChemistryEurope
language:en
Short-container-title:ChemistryEurope

Author:

Mohy El‐Dine Tharwat¹²,Lavayssiere Matthieu¹^ORCID,Adihou Hélène³,Subra Gilles¹,Métro Thomas‐Xavier¹⁴,Ludemann‐Hombourger Olivier³,Lamaty Frédéric¹^ORCID

Affiliation:

1. IBMM Univ Montpellier, CNRS, ENSCM Montpellier France

2. Current address: PolyPeptide Group 67100 Strasbourg France

3. PolyPeptide Group 67100 Strasbourg France

4. Current address: ICGM, CNRS, UM, ENSCM 34293 Montpellier France

Abstract

AbstractThe solventless synthesis of peptides from unactivated amino acids was optimized in a twin‐screw extruder (TSE). The general method enabled the preparation of dipeptides and tripeptides with no epimerization. This flow mechanochemistry approach was applied to the synthesis of aspartame, a synthetic dipeptide, prepared in a continuous mode on large scale and with high productivity.

Funder

Institut Carnot Chimie Balard Cirimat

Publisher

Wiley

Reference66 articles.

2. Synthetic therapeutic peptides: science and market

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5. Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production

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