Sensitive Amperometric Detection of Hydroxylamine at Electropolymerized Curcumin Film Coated Pencil Graphite Electrode

Abstract

AbstractIn this study, a sensitive electrochemical method was developed for the determination of hydroxylamine (H−A) using a curcumin‐modified pencil graphite electrode prepared with the electropolymerization of curcumin (PolyCurc‐PGE). The PolyCurc‐PGE showed a remarkable electrocatalytic response for H−A oxidation compared with bare PGE. Amperometric and cyclic voltammetric measurements were performed based on the electrocatalytic oxidation of H−A at PolyCurc‐PGE. Some parameters, such as monomer concentration, pH, and cycle number during electropolymerization, were optimized to obtain the best electrochemical response of the modified electrode towards H−A. Results show that the PolyCurc‐PGE gives a linear response towards H−A oxidation in the range from 0.50 μM to 500 μM (R2=0.9984). In addition, the sensitivity and detection limit (LOD) of PolyCurc‐PGE were found to be 5432 μA mM−1 cm2 and 0.15 μM H−A, respectively. The developed amperometric method was successfully applied to determine H−A in pharmaceutical and water samples, and acceptable results were obtained with high accuracy and precision.