Tandem Denitrogenation Oxidative Coupling Reaction of Phenyl Vinyl Azides and Cyclic Ethers Under Metal‐Free Conditions

Abstract

AbstractAn efficient synthesis of α‐oxoalkyl ketones is described. The current method is the coupling reaction of phenyl vinyl azides and cyclic ethers under metal‐free conditions. The reaction is conducted with KI as the additive and TBHP (70 % solution in water) as the oxidant at 60 °C for 12 h. A wide range of α‐oxyalkylated ketones with broad functionalities has been synthesized in moderate to good yields.