Formylation of Propargylic Alcohols with Difluorocarbene

Abstract

AbstractA method for the synthesis of propargylic formates from propargylic alcohols and sodium chlorodifluoroacetate is reported. In the reaction, sodium chlorodifluoroacetate is used as a difluorocarbene precursor and a formylating reagent to provide a carbonyl source, while the triple bond of propargylic alcohols is not involved. The method shows convenient operation, good functional group tolerance and high site‐selectivity under mild reaction conditions.