Regioselective Synthesis of Imidazo[1,5‐ b ]pyridazines by Cascade Cyclizations of 1,2‐Diamino‐4H‐phenylimidazole with 1,3‐Diketones, Acetoacetic Ester and Their Derivatives-Reference-Cited by-同舟云学术

Regioselective Synthesis of Imidazo[1,5‐ b ]pyridazines by Cascade Cyclizations of 1,2‐Diamino‐4H‐phenylimidazole with 1,3‐Diketones, Acetoacetic Ester and Their Derivatives

Published:2021-06-18 Issue:23 Volume:6 Page:5801-5806
ISSN:2365-6549
Container-title:ChemistrySelect
language:en
Short-container-title:ChemistrySelect

Author:

Kruzhilin Alexey A.¹,Kosheleva Evgeniya A.¹,Shikhaliev Khidmet S.¹,Denisov Gleb L.²,Vandyshev Dmitriy Yu.¹^ORCID

Affiliation:

1. Department of Organic Chemistry Voronezh State University 1 Universitetskaya ploschad Voronezh Russia

2. Center of the Molecular Structure Study A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences 119991 Vavilova str. 28 Moscow Russia

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/slct.202101372

Reference34 articles.

2. Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

3. Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

4. Multidomain Targeting of Bcr-Abl by Disruption of Oligomerization and Tyrosine Kinase Inhibition: Toward Eradication of CML

5. A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

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