Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors-Reference-Cited by-同舟云学术

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Published:2012-08 Issue:15 Volume:22 Page:4967-4974
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Peterson Emily A.,Boezio Alessandro A.,Andrews Paul S.,Boezio Christiane M.,Bush Tammy L.,Cheng Alan C.,Choquette Deborah,Coats James R.,Colletti Adria E.,Copeland Katrina W.,DuPont Michelle,Graceffa Russell,Grubinska Barbara,Kim Joseph L.,Lewis Richard T.,Liu Jingzhou,Mullady Erin L.,Potashman Michele H.,Romero Karina,Shaffer Paul L.,Stanton Mary K.,Stellwagen John C.,Teffera Yohannes,Yi Shuyan,Cai Ti,La Daniel S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. mTOR: from growth signal integration to cancer, diabetes and ageing

2. Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin

3. Temsirolimus

4. Phase 3 trial of everolimus for metastatic renal cell carcinoma

5. The PTEN–PI3K pathway: of feedbacks and cross-talks

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