Green Synthesis of 2‐Thioxo‐4‐quinazolinone Derivatives in Water

Abstract

AbstractA series of biologically important 3‐substituted‐2‐thixo‐4‐quinazolinones have been synthesized starting from methyl 2‐isothicyanatobenzoate and amines without the use of additives under mild reaction conditions in water. This transformation tolerates a wide range of amines, which include anilines, alkyl amines, and hydrazines, to afford 60 diverse 3‐substituted‐2‐thixo‐4‐quinazolinones including 34 new compounds at 60 °C for 30 min in good yields. This method avoids the use of organic solvent and the generation of toxic waste to demonstrate a cost efficient, green and sustainable method for the synthesis of 2‐thixo‐4‐quinazolinone derivatives as valuable heterocycles for biological and materials studies.