Affiliation:
1. Institute of Chemistry Vietnam Academy of Science and Technology Hanoi Vietnam
2. School of Chemical Engineering Hanoi University of Science and Technology Hanoi Vietnam
Abstract
AbstractNovel green synthesis protocols of 2‐thioxo‐4‐quinazolinones starting from 2‐aminobenzamide and isothiocyanates have been reported. Method A: the reaction was carried out at 60 °C, in water, reaction time of 16 h. Method B: The reaction was carried out under solvent‐free conditions at 100 °C for 16 h. Based on these methods, six 2‐thixo‐4‐quinazolinone derivatives were synthesized with good yield. These methods have advantages, including no use of organic solvents, additives that avoid the generation of toxic waste, simple processes, cost‐effectiveness, good yields, ease of product isolation, and purification.